![]() ![]() In addition, NPS2143 as a negative allosteric modulator of human CaSR negatively modulated the response of cCaSR. Several L-amino acids and kokumi substances such as glutathione enhanced the response of cCaSR. We found that cCaSR was activated by extracellular Ca 2+ and Mg 2+ in a dose dependent manner. Next we cloned the c CaSR gene from kidney and transiently transfected human embryonic kidney 293 T (HEK293T) cells with the recombinant c CaSR, or empty vector and looked for the agonists and allosteric modulators (including kokumi substances) of cCaSR by Ca 2+ imaging. First we confirmed that cCaSR is expressed in taste cells. In this study, we focused on chicken CaSR (cCaSR) since calcium is an essential nutrient that is necessary for making eggshell and for the extremely rapid initial growth of bones. CaSR is also expressed in mammals including rodent taste cells and is involved in sensing kokumi, a rich, savory quality that enhances the intensities of salty, sweet, and umami tastes. ![]() In vertebrates, the extracellular calcium-sensing receptor (CaSR) plays a key role in calcium homeostasis by sensing slight changes in extracellular Ca 2+. ![]()
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December 2022
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